Start: 2000
Duration: Completed 2007

Budget: €7.9 M
(GSMA = €2.9M)

Page last updated: 20/12/07

GSMA: Long Term Animal Studies of Cancer

Starting in 2001, four laboratories in Europe conducted a series of six animal studies investigating whether mobile phone signals at 900 MHz or 1800 MHz are carcinogenic or co-carcinogenic in rats and mice. Funding was received under the EU 5th Framework Program with sponsorship from the GSMA, the MMF, Elettra2000 and national authorities from Austria and Switzerland. In addition a related study was supported at Zhejiang University (China) with encouragement from the WHO.

The objective of these seven studies (known collectively in Europe as PERFORM-A) is to provide high quality and reliable data for risk assessments by the World Health Organization (WHO) and the International Agency for Research on Cancer (IARC). In particular, these studies address the WHO research agenda recommendations for long term animal bioassays for cancer induction/promotion as well as follow-up previously reported findings, most notably the 1997 study which reported an increase of leukaemia in genetically modified mice exposed to 900 MHz signals, though another study has since failed to confirm this result.

The University of Helsinki coordinated the programme and provided a firewall between the sponsors and the researchers.

Partial results have been published and the findings of the remaining studies were reported at the European Bioelectromagnetics Association scientific conference in France in April 2007 and have been peer reviewed and published. The final reports are also available for PERFORM-A (PDF, 104kb) and the Zhejiang study
(PDF, 1,3mb).

Animal carcinogenicity studies on radiofrequency fields related to mobile phones and base stations, Dasenbrock, Toxicology and Applied Pharmacology, 207(2-S1):342-346, 1 September 2005

Response, thermal regulatory threshold and thermal breakdown threshold of restrained RF-exposed mice at 905 MHz, Ebert et al, Physics in Medicine and Biology, 50(21):5203-5215, 7 November 2005

Study on potential effects of "902-MHz GSM-type wireless communication signals" on DMBA-induced mammary tumours in Sprague-Dawley rats, Hruby et al, Mutation Research/Genetic Toxicology and Environmental Mutagenesis, 649(1-2):34-44 8 January 2008

Methodology of detailed dosimetry and treatment of uncertainty and variations for in vivo studies, Kuster et al, Bioelectromagnetics, 27(5):378-39, July 2006

Carcinogenicity Study of 217 Hz Pulsed 900 MHz Electromagnetic Fields in Pim1 Transgenic Mice, Oberto et al, Radiation Research, 168(3):316-326, September 2007

GSM and DCS Wireless Communication Signals: Combined Chronic Toxicity/Carcinogenicity Study in the Wistar Rat, Smith et al, Radiation Research, 168(4):480-492, October 2007

Carcinogenicity study of GSM and DCS wireless communication signals in B6C3F1 mice, Tillman et al, Bioelectromagnetics, 28(3): 173-187, March 2007

Effects of 900 MHz GSM Wireless Communication Signals on DMBA-Induced Mammary Tumors in Rats, Yu et al, Radiation Research, 165(2):174-180, February 2006